According to WHO, the rates of smear-negative and extra-pulmonary pulmonary\ntuberculosis are increasing in high prevalence HIV epidemic areas.\nDelays in diagnosis of tuberculosis can lead to large excess of mortality. It is\nextremely important to provide a strong diagnosis tool of tuberculosis if we\nwant to reduce mortality due particularly to TB co-infection in HIV infected\npeople in low-income countries such as Togo. This study aims to assess the\nperformance of Determineâ?¢ TB LAM Antigen, a rapid diagnostic test (RDT)\nfor tuberculosis. It was an evaluation study, conducted at the National Reference\nLaboratory for Mycobacteria located at the Sylvanus Olympio University\nTeaching Hospital in Lome, Togo from 01 July to 15 November 2017. We\nperformed the assessment onto 100 urine specimens collected from 100 subjects\n(HIV-infected or not). The test allows qualitative detection of the Lipo\nArabinno Mannan (LAM) antigen of Mycobacteria in the urine. Bacilloscopy\nwas chosen as gold standard. Overall, the test Determineâ?¢ TB LAM presented\na sensitivity of 31.25% and a specificity of 95%. In contrast, the sensitivity\nand specificity of the test were respectively 82.35% and 66.67% in the\ngroup of HIV-infected subjects. In HIV non-infected subjects, the sensitivity\nwas 17.46% and the specificity was 100%. Determineâ?¢ TB LAM Antigen test\ncan help detect TB in HIV-infected people unable to expectorate in our settings.
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